Physicians M. Fowler and R. F. Carter first identified and described a disease caused by amoeba-flagellates in Australia in 1965 that affected 4 patients. The amoebas could effectively live both freely in the environment and in a human host. The earliest known confirmed case of Naegleria fowleri was a patient from Virginia in 1937, but the case wasn’t filed until 1968, when Dr. Santos identified the PAM patient after reviewing autopsy samples.
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